AstraZeneca and Merck Report Result of Lynparza (olaparib) in P-III POLO Trial for BRCA-Mutated Metastatic Pancreatic Cancer #ASCO2019

AstraZeneca and Merck Report Result of Lynparza (olaparib) in P-III POLO Trial for BRCA-Mutated Metastatic Pancreatic Cancer #ASCO2019

Shots:

  • The P-III POLO study involves assessing of Lynparza (olaparib, 300mg, bid) vs PBO in 154 patients in ratio (3:2) with BRCAm metastatic pancreatic cancer whose disease had not progressed on 1st-line Pt-based CT
  • The P-III POLO study results: improvement in PFS (7.4 vs 3.8mos.); @1yr & 2yrs. no disease progression ( 34% & 22% vs 15% & 10%) respectively
  • Lynparza (olaparib) is a PARP inhibitor targeted for DNA damage response (DDR) pathway deficiencies, including BRCA mutations. In 2017, Merck and AstraZeneca collaborated to co-develop and co-commercialize Lynparza globally

Click here, Click here to read full press release/ article | Ref: AstraZeneca | Image: AstraZeneca