Janssen Reports New Analysis of Xarelto (rivaroxaban) + Aspirin from the P-III (VOYAGER PAD) Trial for PAD and Co-Morbid Conditions
Shots:
- The P-III (VOYAGER PAD) trial evaluates Xarelto (2.5mg, bid) + aspirin (100mg, qd) vs aspirin alone in a ratio (1:1) in 6564 patients with PAD with/out CKD & with/out the history of statin therapy
- The results showed a reduction in thrombotic hospitalizations due to thrombotic events (8.7% vs 12.1%) for PAD patients with/out CKD, 4.7% ARR in the subgroup with CKD (7.9% vs 12.6%)
- The analysis showed that patients who received Xarelto + aspirin in addition to statin therapy had a 19% reduction in 1EPs composite of ALI, 26% of MALE & 32% in acute limb injury & reduced the composite of MACE or MALE after revascularization for PAD. Both analyses showed a numerical increase in TIMI major bleeding
Ref: Janssen | Image: Janssen
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