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Merck Provides Update of Keytruda (pembrolizumab) in P-III (KEYNOTE-412) Trial for Head and Neck Squamous Cell Carcinoma

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Merck Provides Update of Keytruda (pembrolizumab) in P-III (KEYNOTE-412) Trial for Head and Neck Squamous Cell Carcinoma

Shots:

  • The P-III (KEYNOTE-412) trial evaluating Keytruda (200mg, q3w) + CRT (cisplatin + radiation) vs PBO + cisplatin & CRT as maintenance therapy in 780 adults with unresected LA HNSCC
  • The trial failed to meet its 1EPs of EFS. In the final analysis, the therapy sword an improvement in EFS in patients with Keytruda but did not meet statistical significance per the pre-specified statistical plan & the safety profile was consistent with prior reported studies in HNSCC
  • Keytruda is currently approved as monothx. & in combination regimens in the US, EU, China, Japan & other countries globally for the same indication The company has an extensive clinical program in lung cancer & the therapy is being evaluated in multiple registration-enabling studies

Ref: Bussinesswire | Image: Merck

 

Click here to­ read the full press release 

Senior Editor

Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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