Merck and Eisai Provide P-III (LEAP-002) Trial Update of Keytruda (pembrolizumab) + Lenvima (lenvatinib) for Unresectable Hepatocellular Carcinoma
- The P-III (LEAP-002) trial evaluating Keytruda + Lenvima vs Lenvima monothx. in a ratio (1:1) in 794 patients with uHCC
- The trial failed to meet its dual 1EPs of OS & PFS in patients with uHCC, trends toward improvement in OS & PFS but these results did not meet statistical significance per the pre-specified statistical plan, m-OS of the Lenvima monothx. was longer than that observed in prior reported clinical trials. The safety profile of Keytruda + Lenvima was consistent with prior reported data on the combination
- The results are expected to be presented at an upcoming medical conference. Keytruda is currently approved as monothx. in the US, EU, China, Japan & other countries globally for the same indication
Ref: Businesswire | Image: Merck
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