Ikena Oncology Entered into a Clinical Trial Collaboration Agreement with AstraZeneca for IK-930 to Treat EGFR-Mutated Non-Small Cell Lung Cancer
- The companies collaborated to evaluate Tagrisso + Ikena’s IK-930 for EGFRm NSCLC. The companies also provided an R&D update on IK-930, a TEAD inhibitor addressing the Hippo signaling pathway
- IK-930 is currently being evaluated as a monothx. in a first-in-human P-I trial for advanced solid tumors incl. NF2-deficient malignant mesothelioma & initial clinical results are expected in 2023
- In the preclinical studies, IK-930 + osimertinib resulted in increased induction of apoptosis & improved anti-tumor activity in multiple EGFRm tumor models. The results will be presented at upcoming conferences on the effectiveness and differentiation of IK-930 in multiple animal models as monothx. and in combination with other targeted therapies
Ref: Globenewswire | Image: AstraZeneca
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