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Pfizer Reports P-III Trial Results of Zavegepant for the Acute Treatment of Migraine in Adults

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Pfizer Reports P-III Trial Results of Zavegepant for the Acute Treatment of Migraine in Adults

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  • The P-III trial evaluates zavegepant (10mg) vs PBO in a ratio (1:1) in 1405 patients. The study met its co-primary EPs i.e., zavegepant was more effective than PBO for pain freedom (24% vs 15%) & freedom from the most bothersome symptom (40% vs 31%) @2hr. post-dose
  • Relief from migraine pain in 15min. with relief lasting ~48hr., treatment with zavegepant was associated with higher rates of return to normal functional ability at 30min. post-treatment & 2hrs. The results were published in The Lancet Neurology
  • The therapy was well tolerated with no serious AEs & the safety profile was consistent with earlier studies with no signal of hepatotoxicity due to zavegepant. Intranasal zavegepant's NDA was submitted to the US FDA & an anticipated PDUFA for completion of the review in Q1’23

Ref: Pfizer | Image: Pfizer

Related News:- Biohaven Reports Results of Zavegepant in P-III Study for the Treatment of Migraine

Click here to­ read the full press release 

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Neha is a Senior Editor at PharmaShots. She is passionate and very enthusiastic about recent updates and developments in the life sciences and pharma industry. She covers Biopharma, MedTech, and Digital health segments along with different reports at PharmaShots. She can be contacted at connect@pharmashots.com.

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