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AbbVie Reports Results of Depatux-M (depatuxizumab mafodotin) in P-III INTELLANCE-1 Study for Glioblastoma

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AbbVie Reports Results of Depatux-M (depatuxizumab mafodotin) in P-III INTELLANCE-1 Study for Glioblastoma

Shots:

  • The P-III study results involves assessing of Depatux-M (depatuxizumab mafodotin- ABT-414) + SOC therapy of radiation + temozolomide vs PBO + SOC in 639 patients with newly diagnosed EGFR-amplified GBM
  • AbbVie has halted the enrollment of patients in all ongoing studies of Depatux-M due to its inability to meet 1EP- demonstrated no survival benefits & no new safety is observed. IMDC has also recommended for the termination of INTELLANCE-1 study due to lack of survival benefits
  • Depatux-M (depatuxizumab mafodotin) is an ADC targeting EGFR-amplification- evaluated to treat glioblastoma under the collaboration of AbbVie & RTOG foundation

Ref: AbbVie | Image:AbbVie

Click here to­ read the full press release 

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