Merck Reports P-III Trial (NRG-GY018) Results of Keytruda (pembrolizumab) as 1L Treatment for Advanced or Recurrent Endometrial Carcinoma
- The P-III trial (NRG-GY018) evaluating Keytruda + CT vs PBO + CT alone in 819 patients with measurable stage III, IVA, IVB, or recurrent endometrial cancer in pMMR and dMMR cohorts. NCI sponsored the trial
- The trial met its 1EPs i.e., improvement in PFS at a pre-specified interim analysis. The safety profile was consistent with prior reported studies with no new safety signals & the results will be presented at an upcoming medical meeting & discussed with regulatory authorities
- The company has a comprehensive clinical development program in EC. Keytruda is being studied as monotx. (KEYNOTE-C93/ENGOT-en15/GOG-3064) & in combination with Lenvima (LEAP-001/ENGOT-en9) for 1L advanced EC along with adjuvant setting (KEYNOTE-B21/ENGOT-en11/GOG-3053)
Ref: Merck | Image: Merck
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