InDex Pharmaceuticals Reports Positive PK Results from Cobitolimod in Patients with Ulcerative Colitis
- 7 patients treated with cobitolimod (500 mg, rectally). After initial administration plasma concentrations were measured in all 7 patients during a flare, then the degree of clinical remission at week 6 was evaluated on the re-administration of cobitolimod at week 3
- Of 7 patients, 4 patients achieved CR at week 6. After third dose, a second PK analysis was conducted to evaluate systemic uptake of cobitolimod also in patients with remission
- The results showed a limited systemic uptake for both patients in a flare and in remission, with the majority of patients having undetectable levels of cobitolimod in the plasma after 8hrs. Cobitolimod was well tolerated, along with no SAEs were reported
Ref: prnewswire | Image: InDex Pharmaceuticals
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