Novartis to Present Five-Year (ALITHIOS) Open-Label Extension Study Results of Kesimpta (ofatumumab) for Relapsing Multiple Sclerosis at AAN 2023
Shots:
- The (ALITHIOS) OLE study evaluating Kesimpta which showed continuous treatment with Kesimpta for ~5yr. was associated with fewer confirmed disability worsening events vs those who switched later from teriflunomide to Kesimpta
- ~80% remained free of 6mos. CDW, low brain volume change over 5yr. favored earlier initiation of Kesimpta, ABVC in the core P-III trials for continuous Kesimpta was -0.34%/yr. vs switch group (-0.42%/yr.) while -0.27%/yr. vs -0.28%/yr. in the extension
- In the separate analysis, the therapy was well-tolerated with no new or increased safety risks, overall rates of AEs & SAEs were consistent with the core P-III trials, IgG levels remained stable @~5yr., treatment interruption/discontinuation due to low lgG & lgM in (0.2% & 10.3%)/ (0.2% & 3.6%) patients
Ref: Novartis | Image: Novartis
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