Puma Biotechnology Reports Results of PB272 (neratinib) in P-III NALA Trial for Patients with 2L+ HER2+ Metastatic Breast Cancer #ASCO2019

Puma Biotechnology Reports Results of PB272 (neratinib) in P-III NALA Trial for Patients with 2L+ HER2+ Metastatic Breast Cancer #ASCO2019

Shots:

  • The P-III NALA trial involves assessing of neratinib + capecitabine vs Tykerb (lapatinib) + capecitabine in 621 patients in ratio (1:1) with 3L HER2-positive metastatic breast cancer
  • P-III NALA Trial results: mPFS (8.8 mos. vs 6.6 mos.); mOS (21.0 mos. vs 18.7 mos.); mean OS @48 mos. (24.0 mos. vs 22.2 mos.); overall cumulative incidence of CNS metastases (22.8% vs 29.2%); DOR (8.54 mos. vs 5.55 mos.); TEAEs (10.9% vs 14.5%)
  • PB272 is a tyrosine kinase inhibitor and its oral formulation has received the US FDA’s approval for the extended adjuvant treatment in adults with early stage HER2-overexpressed/amplified breast cancer in Jul’17, marketed as Nerlynx (neratinib) tablets in the US

Click here to read full press release/ article | Ref: Puma Biotechnology | Image: ID Works Global