Shots:

• The P-III TOURMALINE-AL1 (NCT01659658) study involves assessing of Ninlaro + dexamethasone vs dexamethasone + (melphalan/ cyclophosphamide/ thalidomide/ lenalidomide)/ monothx in patients with relapsed or refractory systemic light chain (AL) amyloidosis
•  The P-III TOURMALINE-AL1 study resulted in unmet 1EPs as well as demonstrated no improvement in overall hematologic response leading to its discontinuation
• Ninlaro (ixazomib) is an oral proteasome inhibitor currently evaluated in multiple myeloma and is approved in 60+ countries including the US- Japan and EU with 10+ regulatory filings under review

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