Sanofi Reports P-IIb Study (STREAM-AD) Results of Amlitelimab for the Treatment of Atopic Dermatitis
- The P-IIb study evaluating amlitelimab, a fully human non-depleting mAb that binds to OX40-Ligand vs PBO in 390 adult patients across Australia, Bulgaria, Canada, Czechia, Germany, Hungary, Japan, Poland, Spain, Taiwan, the UK & the US
- The trial met its 1EPs & showed an improvement in avg. EASI score from baseline at 16wks. for all 4 subcutaneous doses, improvements + also seen in 2EPs at 16 & 24wks. with continued improvement through 24wks. in primary & secondary outcomes while biomarker results support an effect on type 2 & non-type 2 pathways
- The therapy was well-tolerated across all dose arms with no new safety concerns. Amlitelimab is designed to restore immune homeostasis b/w pro-inflammatory & regulatory T cells by targeting the OX40-ligand
Ref: Sanofi | Image: Sanofi
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