AstraZeneca and MSD's Lynparza (olaparib) Receive European Commission's Approval as 1L Maintenance Treatment for BRCA-Mutated Advanced Ovarian Cancer
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- The approval is based on P-III SOLO-1 study result assessing Lynparza (300mg- bid) as a maintenance monothx. vs PBO in 391 patients in ratio (2:1) with BRCA-mutated advanced ovarian cancer following 1L platinum-based CT
- The P-III SOLO results demonstrated that 60% of patients showed disease-free progression after three yrs. of treatment and only 27% in patients receiving placebo
- Lynparza is a PARP inhibitor- act by blocking DNA damage response (DDR) in cells/tumors and has received approval in 60+ countries including the US- EU as 1L maintenance treatment for BRCAm advanced ovarian cancer and in 40+ countries for germline BRCAm HER2-negative metastatic breast cancer
Ref: AstraZeneca | Image: AstraZeneca
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