Ironwood and Allergan Report Positive Results of Inzess (linaclotide) in P-IIIb Trial for Patients with Irritable Bowel Syndrome with Constipation

Ironwood and Allergan Report Positive Results of Inzess (linaclotide) in P-IIIb Trial for Patients with Irritable Bowel Syndrome with Constipation

Shots:

  • The P-IIIb study results involve assessing of Inzess (290 mcg, qd) vs PBO in 614 adult patients on multiple abdominal symptoms with IBS-C
  • The P-III study results met its 1EPs & 2EPs demonstrating overall improvement in abdominal symptoms of bloating, pain and discomfort in adults, decrease in weekly abdominal score 29.7% vs 18.3%; clinically meaningful response (40.5% vs 23.4%); diarrhea (4.6% vs 1.6%)
  • Linaclotide is a guanylate cyclase-C (GC-C) agonist binds to GC-C receptor locally, approved in the US for IBS-C or chronic idiopathic constipation (CIC) and is marketed in EU for moderate to severe IBS-C with brand name Constella

Click here to read full press release/ article | Ref: Ironwood | Image: Occam Global