Roche’s Tecentriq Receives EU’s CHMP Recommendation for its Approval as 1L Therapy for Extensive-Stage Small Cell Lung Cancer

Roche’s Tecentriq Receives EU’s CHMP Recommendation for its Approval as 1L Therapy for Extensive-Stage Small Cell Lung Cancer

Shots:

  • The CHMP’s positive recommendation is based on P-III IMpower133 study results assessing Tecentriq + CT vs CT (carboplatin and etoposide) in 403 patients in a ratio (1:1) with ES-SCLC
  • The P-III IMpower133 study results: OS (12.3 vs 10.3 mos.); PFS (5.2 vs 4.3 mos.). Tecentriq based combination therapy is expecting its European Commission’s approval following the CHMP’s positive recommendation
  • Tecentriq is a mAb targeting PD-L1, blocking its interaction with PD-1 and B7.1 receptor, thus enabling the interaction of T-cells and is an approved therapy for multiple cancer indications in the US & EU

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