Shots:

• The approval is based on P-I/III IMpower133 study assessing Tecentriq (1200mg- IV-) + CT (carboplatin and etoposide) q3w over 60mins.- if tolerated subsequent infusion can be administered over 30mis. vs CT as monothx. in patients with extensive-stage small-cell lung cancer
• The P-I/III IMpower133 study results: median OS (12.3 vs 10.3mos.); m-PFS (5.2 vs 4.3mos.); safety profile was consistent with the previous study; no new safety signals is observed
• Tecentriq (atezolizumab) is a mAb targeting PD-L1- blocking its interaction with PD-1 and B7.1 receptor and becomes the new therapy option for patients with extensive-stage SCLC in 17yrs.

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Ref: Chugai Pharmaceutical | Image: Roche