Alexion to Acquire Syntimmune for antibody therapeutics targeting the neonatal Fc receptor (FcRn)

Alexion to Acquire Syntimmune for antibody therapeutics targeting the neonatal Fc receptor (FcRn)

Shots:

  • Alexion to acquire Syntimmune for $1.2B in cash, including an upfront payment of $400M, with additional milestone payments of up to $800M. The transaction is expected to close in Q4’18
  • Alexion to get the SYNT001 through this acquisition, which a humanized monoclonal antibody, which inhibits the binding of FcRn with Immunoglobulin G (IgG) and IgG immune complexes. It is being developed for the treatment of IgG-mediated rare diseases
  • SYNT001 is currently tested in P-Ib/IIa studies for warm autoimmune hemolytic anemia (WAIHA) and pemphigus vulgaris (PV) or pemphigus foliaceus (PF) and has been validated in rapid IgG reduction

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