Vertex Collaborates with Molecular Templates to Discover and Develop Conditioning Regimens Enhancing Hematopoietic Stem Cell Transplants

Vertex Collaborate with Molecular Templates to Discover & Develop Conditioning Regimens Enhancing Hematopoietic Stem Cell Transplants

Shots:

  • Molecular Templates (MTEM) to receive $38M up front including an equity investment, up to $522M as development, regulatory, commercial milestones, option payment for two targets and royalties on sales of products
  • MTEM will conduct research activities to discover a new conditioning regimen utilizing its engineered toxin body (ETB) platform for up to two targets selected by Vertex including CTX001. Additionally, Vertex will get an option to select a second target and to license selected molecules with an exclusive right to develop selected molecules for any indication
  • CTX001 is an ex vivo CRISPR/Cas9 gene editing therapy, currently being evaluated in two ongoing P-I/II studies in patients with transfusion-dependent beta thalassemia and severe sickle cell disease, where a hematopoietic stem cell transplant is required as part of treatment with CTX001

Click here to­ read full press release/ article | Ref: Vertex | Image: Pharma Advancement