Takeda’s Takhzyro (lanadelumab injection) Receives CADTH’s CDEC Positive Opinion for the Routine Prevention of Hereditary Angioedema Attacks

Takeda’s Takhzyro (lanadelumab injection) Receives CADTH's CDEC Positive Opinion for the Routine Prevention of Hereditary Angioedema Attacks

Shots:

  • The positive recommendation is based on P-III Help Study Open-label Extension assessing Takhzyro (300mg, q2w) in 212 HAE adolescents and adults aged ≥12 yrs.
  • The P-III Help study OLE results: reduction rate of attacks, reduction in attacks requiring acute treatment (92.6%), reduction in mod. to sev. attacks (83.6%), mean attack rate (87%); 58% & 78% patients showed maximum attack-free period lasted ≥12mos. & ≥6mos. following the first regular treatment dose respectively
  • Takhzyro is a mAb targeting plasma kallikrein activity, indicated for the routine prevention of HAE attacks in patients aged ≥12 yrs. and is an approved therapy in multiple countries including the US, EU, Australia and Switzerland with additional ongoing regulatory submission across the globe

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