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Alnylam and Dicerna Collaborate to Develop and Commercialize RNAi Therapeutics for Alpha-1 Antitrypsin Deficiency-Associated Liver Disease

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Alnylam and Dicerna Collaborate to Develop and Commercialize RNAi Therapeutics for Alpha-1 Antitrypsin Deficiency-Associated Liver Disease

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  • The collaboration will explore Alnylam’s ALN-AAT02 and Dicerna’s DCR-A1AT- each in P-I/II development for the treatment of alpha-1 liver disease. Dicerna will lead the global clinical development and commercialization (US only) of its DCR-A1AT and Alnylam’s ALN-AAT02
  • Post P-III completion- Alnylam retains an option to commercialize the selected candidate outside the US. If Alnylam exercises its opt-in right- both the companies will pay royalties to each other based on the commercialization of the product and if it waives its option- Alnylam will receive milestones and royalties while Dicerna retain global rights to commercialize the selected candidate
  • Additionally- companies have completed a non-exclusive IP cross-license agreement for the development and commercialization of Alnylam’s lumasiran and Dicerna’s nedosiran for PH. Under the cross-license agreement- Alnylam will pay royalties to Dicerna on the global sales of lumasiran and Dicerna will pay royalties to Alnylam on global sales of nedosiran

Click here ­to­ read full press release/ article | Ref: Alnylam | Image: Dicerna


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