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Merck's Keytruda (pembrolizumab) Receives FDA Approval for the Treatment of Hepatocellular Carcinoma (HCC)

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Merck's Keytruda (pembrolizumab) Receives FDA Approval for the Treatment of Hepatocellular Carcinoma (HCC)

Shots:

  • The KEYNOTE-224 study involves assessing of Keytruda (200mg q3w @24mos) in 104 patients with HCC aged ≥65- previously treated or intolerant to sorafenib
  • KEYNOTE-224 study results: ECOG PS 0 or 1 (61% or 39%); Child Pugh class A5/A6/B7/B8 (72%/22%/5%/1%); HBV & HCV seropositive (21% & 25%); ORR (17%); CR (1%); PR (16%); mDOR @ 6mos.&12mos. (89% & 56%)
  • Keytruda is a mAb- works as an anti-PD -1 therapy for tumor cells and has received 14 approvals including one for HCC & is evaluated in > 850 trials in for different cancers

Ref: Merck | Image: Merck 


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