Insights+ Exclusive: COVID-19 Healthcare News Monthly Updates – June 2020

COVID Updates JUNE

Our planet is facing a major pandemic outbreak due to COVID-19 and health agencies are taking every measure to stop it. The COVID-19 virus has been named “SARS-CoV-2” (severe acute respiratory syndrome coronavirus 2) and the disease it causes has been named “Coronavirus Disease 2019” (COVID-19). The outbreak of the respiratory disease was first detected in Wuhan City, Hubei Province, China in Dec 2019. Life sciences companies are putting all of their efforts into finding a treatment or developing a vaccine for this disease. PharmaShots is keeping a track of all of the important updates in the Lifesciences sector, where we have covered news updates regarding collaborations, clinical trials, funding, and regulatory guidelines related to the COVID-19 from Jan to date. 

156.  EMA and Korean Ministry of Food and Drug Safety to Share Confidential COVID-19 Information

Jun 30, 2020 | Regulatory

155. TRI Initiates ETHIC Trial to Evaluate the Potential Benefits of Early Administration of LMWH in Patients with COVID-19

Jun 30, 2020 | Clinical Trial

154. Health Canada Allows COVID-19 Patients with Respiratory Failure to Be Given NuvOx Pharma’s Oxygen Therapeutic in P-IIa Clinical Trial

Jun 30, 2020 | Clinical Trial

152. RedHill Biopharma Receives Approval for COVID-19 P-I/II Study with Opaganib in the UK

Jun 29, 2020 | Regulatory

151. Cytocom to Initiate P-II Clinical Trial of CYTO-201 in COVID-19 Patients

Jun 29, 2020 | Clinical Trial

150. US Department of Defense to Fund Altimmune’s P-I/II Study of T-COVID in Outpatients with Early COVID-19

Jun 29, 2020 | Grant

149. RevImmune Initiates P-II Trial of the T-Cell Growth Factor CYT107 for COVID-19

Jun 29, 2020 | Clinical Trial

148. Sanford Burnham Prebys Collaborated with Lilly for COVID-19 Antibody Research

Jun 29, 2020 | Collaboration

147. PEEL Therapeutics Announces New Treatment for COVID-19

Jun 29, 2020 | Clinical Trial

146. Gilead Unveils the Price of Remdesivir as $390 per Vial in Developed Countries

Jun 29, 2020 | Pharma

145. Bharat Biotech to Initiate Clinical Trials Evaluating Covaxin (India’s First COIVD-19 Vaccine) in July 2020

Jun 29, 2020 | Clinical Trial

144. Trial of Oxford’s COVID-19 Vaccine Starts in Brazil

Jun 28, 2020 | Clinical Trial

143. Daiichi Sankyo in Talks with AstraZeneca for the Supply of AZD1222 to Combat COVID-19 in Japan

Jun 29, 2020 | Collaboration

142. EMA Anticipate the EC’s Conditional Marketing Authorization for Gilead’s Remdesivir in Next Week

Jun 25, 2020 | Regulatory

141. LabCorp Launches New Neutralizing Antibody Test for COVID-19

Jun 25, 2020 | Diagnostic

140. Noxopharm to Commence COVID-19 Study in Europe

Jun 25, 2020 | Clinical Trial

139.  Applied Biology Collaborate with Brown University Researchers and Corpometria Institute to Launch ANDROCOV Study for COVID-19

Jun 25, 2020 | Clinical Trial

138. Algernon Receives Ethics Approval for P-IIb/III Study of Ifenprodil for COVID-19

Jun 25, 2020 | Regulatory

137. Avalon GloboCare Achieves Milestones in Advancing Novel Intranasal and Oral COVID-19 Vaccine Candidate

Jun 25, 2020 | Clinical Trial

136. Stevanato Group Signs an Agreement with the CEPI to Provide Pharma Glass Vials for 2B Doses of COVID-19 Vaccine

Jun 25, 2020 | Collaboration

135.  Moderna and Catalent Collaborates for Fill-Finish Manufacturing of Moderna’s COVID-19 Vaccine Candidate

Jun 25, 2020 | Collaboration

133.  Theravance Reports First Patient Dosing in a P-II Study of TD-0903 for Hospitalized Patients with Acute Lung Injury Associated with COVID-19

Jun 25, 2020 | Clinical Trial

132. Repertoire Immune Medicines Receives Funding From COVID-19 High Performance Computing Consortium

Jun 24, 2020 | Grant

131. UW–Madison and UW Health Launch COVID-19 Clinical Trials

Jun 24, 2020 | Clinical Trials

130. Global Regulators Discuss Data Requirements for P-III Trials of COVID-19 Vaccines

Jun 24, 2020 | Regulatory

129. iBio Selected by IBM Watson Health for the use of IBM Clinical Development Solution at No Cost to help Support clinical COVID-19 Vaccine Candidates

Jun 24, 2020 | Grant

128. ICER Provides First Update to Pricing Models for Remdesivir as a Treatment for COVID-19

Jun 24, 2020 | Regulatory

127.  NeuroRx and Relief Therapeutics Receive the US FDA’s FT Designation for its RLF-100 (Aviptadil) to Treat Respiratory Distress in COVID-19

Jun 24, 2020 | Regulatory

126. Fulcrum Initiates P-III LOSVID Study Evaluating Losmapimod for Patients Hospitalized with COVID-19

Jun 24, 2020 | Clinical Trial

125. Sanofi Anticipates the Approval of its COVID-19 Vaccine by First Half of 2021

Jun 23, 2020 | Clinical Trial

124. AstraZeneca Signs an Agreement with Symbiosis for Sterile Manufacturing of its AZD1222 Against COVID-19

Jun 23, 2020 | Collaboration

123. FibroGen Report Enrollment of First Patient in P-II Study Evaluating Pamrevlumab in Patients Hospitalized with Acute COVID-19

Jun 23, 2020 | Clinical Trial

122.  Frontier Scientific Develops and Provides Process to Produce Active Pharmaceutical Ingredient for Clinical Trial of COVID-19 Therapeutic Investigational Drug RBT-9

Jun 23, 2020 | Clinical Trial

121. Renibus Therapeutics Receives FDA Fast Track Designation for RBT-9 Treatment in COVID-19

Jun 23, 2020 | Regulatory

120. Repurpose.AI and Scripps Research Collaborate to Discover COVID-19 Therapeutics

Jun 23, 2020 | Collaboration

119. Inivio Receives $71M Contract from US Department of Defense to Scale Up Manufacture of CELLECTRA 3PSP Smart Device and Procurement of CELLECTRA 2000 for COVID-19 DNA Vaccine

Jun 23, 2020 | DigiHealth

118. Schrödinger Expands its Drug Discovery Efforts Against COVID-19 Deploying Parallel Computing on Google Cloud

Jun 22, 2020 | DigiHealth

117. Gilead to Initiate P-I Study Evaluating Inhaled Version of Remedesivir Against COVID-19 in August 2020

Jun 22, 2020 | Clinical Trial

116. Feinstein Institutes for Medical Research Finds Extended Drug Treatment Reduces Blood Clots in Discharged Patients, a Side-effect of Recovering COVID-19 Patients

Jun 22, 2020 | Clinical Trial

115.  Evelo Biosciences to Advance EDP1815 into P-II/III TACTIC-E COVID-19 Study

Jun 22, 2020 | Clinical Trial

114. Catalent Collaborates with ViralClear Pharmaceuticals on Potential Treatment for COVID-19

Jun 22, 2020 | Collaboration

113.  Orgenesis and Leidos Collaborate on Potential Treatment for COVID-19

Jun 22, 2020 | Collaboration

112. Glenmark Launches FabiFlu (favipiravir) as the First Oral Medication to Treat Mild to Moderate COVID-19 in India

Jun 20, 2020 | Launch

111. Novartis Halts Clinical Trial Evaluating Hydroxychloroquine Against COVID-19 Due to Slow Enrollment

Jun 20, 2020 | Clinical Trial

110.  Cipla Launches Cipremi (remdesivir lyophilised powder for injection 100 mg) to Treat Patients with Severe COVID-19

Jun 19, 2020 | Launch

109. Ampio to Initiate First Clinical Trial in COVID-19 Program

Jun 19, 2020 | Clinical Trial

108. MMR Vaccine Protects Against the Worst Symptoms of COVID-19

Jun 19, 2020 | Regulatory

107. Ridgeback Launches P-II Study Testing EIDD-2801 as Potential Treatment for COVID-19

Jun 19, 2020 | Clinical Trial

106. NICE Publishes Latest COVID-19 Guidance on Renal Transplantation

Jun 19, 2020 | Regulatory

105. Dynavax Report First Patient Dosing in P-I Clinical Trial Evaluating Clover Biopharmaceuticals’ COVID-19 S-Trimer Vaccine Candidate with CpG 1018 Adjuvant

Jun 19, 2020 | Clinical Trial

104.   WHO Testing Interim Data from COVID-19 Study on HIV drugs

Jun 18, 2020 | Regulatory

103.  Codagenix Reports the Synthesis and Preliminary Safety of Scalable of Vaccine Candidate Against COVID-19

Jun 18, 2020 | Clinical Trial

102.   Tonix Pharmaceuticals and Southern Research Expands its COVID-19 Vaccine Collaboration

Jun 18, 2020 | Collaboration

101.  Roche Rheumatoid Arthritis Drug Fails to Help COVID-19 Patients in Italian study

Jun 18, 2020 | Clinical Trial

100.  National Expansion of Synairgen’s Home-Based COVID-19 Trial of Inhaled SNG001

Jun 18, 2020 | Clinical Trial

99. Enrollment in P-II Clinical Trial in Cystic Fibrosis Has Been Resumed in Israel and Europe After Being Paused Temporarily in Response to the COVID-19 Pandemic

Jun 17, 2020 | Clinical Trial

98.  JW Pharmaceutical to Repurpose Targeted Oncology Drug as COVID-19 Therapy

Jun 17, 2020 | Clinical trial

97.  PTC Therapeutics Initiates P-II/III Clinical Trial to Evaluate PTC299 for the Treatment of COVID-19

Jun 17, 2020 | Clinical trial

96.  Kiniksa Announces Lancet Rheumatology Publication of Clinical Outcomes with Mavrilimumab in COVID-19

Jun 17, 2020 | Clinical trial

95.  Cellics Therapeutics Announces the Publication of Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity in Nano Letters

Jun 17, 2020 | Clinical trial

94.  InflaRx Reports Results from the Exploratory P-II Part of the Adaptive Randomized P-II/III Trial of IFX-1 in COVID-19

Jun 17, 2020 | Clinical trial

93.   Aclaris Therapeutics Supports Investigator-Initiated Clinical Trial of ATI-450 for Cytokine Release Syndrome in Hospitalized Patients with COVID-19

Jun 17, 2020 | Clinical trial

92.  Nascent Biotech to Begin Animal Model Studies for Pritumumab Against Coronaviruses and COVID-19

Jun 17, 2020 | Clinical trial

91.   ViralClear Opens Enrollment with First Patient Dosing in P-II Human Trial of Anti-Viral MMPD Oral Solution for Treatment of COVID-19

Jun 17, 2020 | Clinical trial

90.   Innovation Pharmaceuticals’ Brilacidin Inhibits SARS-CoV-2 (COVID-19) by 97 Percent in a Human Lung Cell Line

Jun 17, 2020 | Clinical trial

89.  CORAT Therapeutics Takes Over the Fast Track Development of a Novel COVID-19 Antibody Drug Program

Jun 17, 2020 | Regulatory

88.   BERG Creates New Drug Research Effort to Use Oak Ridge National Laboratory’s Summit Supercomputer in the Fight Against COVID-19

Jun 17, 2020 | Regulatory

87.   CureVac Receives Regulatory Approval from German and Belgian Authorities to Initiate Phase 1 Clinical Trial of its SARS-CoV-2 Vaccine Candidate

Jun 17, 2020 | Regulatory

86.   Kamada Announces Availability of its Plasma-Derived Hyperimmune IgG Therapy for Coronavirus Disease (COVID-19) for Compassionate Use Treatment in Israel

Jun 17, 2020 | Clinical trial

85.   aTyr Pharma Highlights New Literature Implicating Neuropilin Pathway In SARS-CoV-2 Infection

Jun 17, 2020 | Clinical trial

84.  PDS Biotechnology and Farmacore Biotechnology Announce Co-Development of PDS0204 COVID-19 Vaccine

Jun 17, 2020 | Collaboration

83.   PRA Collaborates with Microsoft to Foster COVID-19 Monitoring

Jun 17, 2020 | DigiHealth

82.   Gilead to Initiate P-II/III Study Evaluating Remdesivir in Pediatric Patients Hospitalized With COVID-19

Jun 17, 2020 | Clinical Trial

81.  AstraZeneca Signs an Agreement with Catalent to Manufacture AZD1222 for COVID-19

Jun 16, 2020 | Collaboration

80. Celltrion Anticipates the Launch of its POCT Kit for COVID-19 in July 2020

Jun 16, 2020 | Diagnostic

79.  AstraZeneca Signs an Agreement with Cobra Biologics for Vaccines Against COVID-19

Jun 16, 2020 | Collaboration

78. TrialSpark Reports the launch of Project Covalence to Rapidly Test Drugs and Diagnostics for COVID-19

Jun 16, 2020 | Diagnostic

77.  Repurposing Approved Drugs for COVID-19 at an Accelerated Pace

Jun 16, 2020 | Clinical Trial

76. Humanigen Reports Additional Analysis of Lenzilumab in Severe and Critical COVID-19 Patients

Jun 16, 2020 | Clinical Trial

75. US Research Program Launches COVID-19 Research Initiatives

Jun 16, 2020 | Regulatory

74.  AGC Biologics to Develop and Produce COVID-19 Vaccine

Jun 16, 2020 | Clinical Trial

73.  Arch Biopartners Receives the US FDA’s Apporval to Intiate P- II Trial Evaluating Metablok (LSALT peptide) for the Treatment of COVID-19 Patients

Jun 16, 2020 | Clinical Trial

72.  Monopar and NorthStar Collaborate to Develop Radio-Immuno-Therapeutics (RITs) Targeting Severe COVID-19

Jun 16, 2020 | Collaboration

71.  aTyr Pharma Reports First Patient Dosing in P-II Trial of ATYR1923 in COVID-19 Patients with Severe Respiratory Complications

Jun 15, 2020 | Clinical Trial

70.  Mayo Clinic Study of Humanigen’s Lenzilumab Shows Rapid Recovery and Discharge in Severe and Critical COVID-19 Patients

Jun 15, 2020 | Clinical Trial

69. Immunic Announces First Patients Dosed in its P-II CALVID-1 Clinical Trial of IMU-838 in COVID-19

Jun 15, 2020 | Clinical Trial

68.  Vaxart to Accelerate Advancement of COVID-19 and Other Programs

Jun 15, 2020 | Clinical Trial

67.  Treos Bio Forms New Subsidiary to Develop a Preventive COVID-19 Peptide Vaccine

Jun 15, 2020 | Pharma

66.  Adamis Pharmaceuticals Signs a License to Commercialize Tempol for the Treatment of Respiratory Diseases Including COVID-19

Jun 15, 2020 | Collaboration

65.  NIH Launches Analytics Platform to Harness Nationwide COVID-19 Patient Data to Speed Treatments

Jun 15, 2020 | Regulatory

64.  Edesa Biotech Receives Regulatory Approval to Initiate COVID-19 Study

Jun 15, 2020 | Clinical Trial

63.  FDA Revokes Emergency Use Authorization for Chloroquine and Hydroxychloroquine

Jun 15, 2020 | Regulatory

62.  Eli Lilly Initiates P-III Study Evaluating Baricitinib in Hospitalized Patients with COVID-19

Jun 15, 2020 | Clinical Trial

61.  OncoImmune Provides Update on P-III Clinical Trial of CD24Fc for Severe and Critical COVID-19

Jun 14, 2020 | Clinical Trial

60.  AstraZeneca To Supply 400M Doses of Vaccines to IVA by the End of 2020

Jun 13, 2020 | Clinical Trial

59. Sinovac Reports Results of P-I/II Clinical Trials for Inactivated Vaccine Candidate Against COVID-19

Jun 13, 2020 | Clinical Trial

58.  Gilead Signs a License Agreement with Zydus and Dr. Reddy’s for Remdesivir to Treat COVID-19

Jun 12, 2020 | Clinical Trial

57.  Daiichi Sankyo to Develop Vaccine for COVID-19 in Japan

Jun 12, 2020 | Clinical Trial

56. Regeneron Initiates its First Clinical Study of Antibody Cocktail for the Treatment and Prevention of COVID-19

Jun 11, 2020 | Clinical Trial

55. Moderna to Initiate P-III Study of its mRNA-1273 Against COVID-19 in July 2020

Jun 11, 2020 | Clinical Trial

54.  Sinovac and Butantan to Advance the Clinical Development of an Inactivated Vaccine for COVID-19 to P-III

Jun 11, 2020 | Collaboration

53.  European Investment Bank Fund ~€100M to BioNTech for COVID-19 Vaccine Development and Manufacturing

Jun 11, 2020 | Grant

52. Celltrion to Evaluate Remsima (biosimilar, infliximab) Against COVID-19 in Britain

Jun 10, 2020 | Clinical Trial

51. Sorrento Submits EUA to the US FDA for its COVI-TRACK Test to Detect COVID-19

Jun 10, 2020 | Diagnostic

50.  Johnson & Johnson to Initiate P-I/IIa Clinical Study of its COVID-19 Vaccine in July

Jun 10, 2020 | Clinical Trial

49.   RedHill Biopharma Reports the Submission of CTA for P-II/III Study Evaluating Opaganib Against COVID-19 in Russia

Jun 10, 2020 | Clinical Trial

48.  Tychan to Initiate Clinical Trials for TY027 Against COVID-19

Jun 10, 2020 | Clinical Trial

47.   NIH-Funded Study to Evaluate Drugs Prescribed to Children with COVID-19

Jun 10, 2020 | Grant

46.  Qualigen Signs Exclusive License Agreement with the University of Louisville to Develop AS1411 Against COVID-19

Jun 10, 2020 | Collaboration

45.  Data Supports Continued Use of ACE inhibitors and ARB medicines During COVID-19 Pandemic

Jun 10, 2020 | Regulatory

44. Fulcrum Therapeutics to Evaluate Losmapimod as Potential Treatment for COVID-19

Jun 10, 2020 | Clinical Trial

43. Panacea Biotech and Refana Announce Collaborates for COVID-19 Vaccine

Jun 10, 2020 | Collaboration

42.  APC Collaborates with Vaxine to Develop COVID-19 Vaccine

Jun 10, 2020 | Collaboration

41.   HSA Grants Conditional Approval of Remdesivir for Treatment of COVID-19 Infection

Jun 10, 2020 | Regulatory

40.   Catalent Collaborates with Spicona to Develop COVID-19 Vaccine Candidate using GPEx Cell Line Development Platform

Jun 10, 2020 | Collaboration

39. Alphamab Oncology and Institut Pasteur Shanghai Collaborate to Co-develop COVID-19 Neutralizing Antibody

Jun 09, 2020 | Collaboration

38. Relief Therapeutics and NeuroRx Expand Clinical Trial of RLF-100 to all patients with Critical COVID-19 and Respiratory Failure

Jun 08, 2020 | Clinical Trial

37. Fujifilm Clinical Research May Drag on into July Against COVID-19

Jun 07, 2020 | Clinical Trial

36. China to Strengthen Global Cooperation in COVID-19 Vaccine Studies

Jun 07, 2020 | Clinical Trial

35. AstraZeneca Reports Results of Calquence (acalabrutinib) in CALAVI Study for Hospitalized COVID-19 Patients

Jun 05, 2020 | Collaboration

34. Oxford Biomedica Signs a Five-Year Agreement with the Vaccines Manufacturing and Innovation Centre (VMIC) for AZD1222

Jun 05, 2020 | Collaboration

33. AbbVie Enters into a Collaboration to Develop Monoclonal Antibody Therapy for Preventing COVID-19

Jun 05, 2020 | Collaboration

32. AstraZeneca Signs an Agreement with Serum Institute to Supply 1B Doses of Oxford University’s COVID-19 Vaccine

Jun 05, 2020 | Collaboration

31. Sun Pharma Initiates P-II Clinical Study of AQCH as Treatment for COVID-19 patients

Jun 05, 2020 | Clinical Trial

30. Sorrento Report Preclinical Results of COVIDTRAP (STI-4398) to Treat COVID-19

Jun 05, 2020 | Clinical Trial

29. ONO Initiates Clinical Studies Evaluating Foipan for COVID-19

Jun 05, 2020 | Clinical Trial

28. The University of Queensland, CEPI and CSL Collaborate to Advance Development and Manufacture of COVID-19 Vaccine Candidate

Jun 05, 2020 | Collaboration

27. ViralClear Expands Patient Enrollment its Planned Phase II Merimepodib for COVID-19

Jun 05, 2020 | Clinical Trial

26. RECOVERY Study Demonstrated No Clinical Benefits for Using Hydroxychloroquine in Hospitalized Patients with COVID-19

Jun 05, 2020 | Clinical Trial

25. Intravacc and EpiVax Collaborate to Develop an Emerging Vaccine for COVID-19

Jun 04, 2020 | Collaboration

24. Inovio to Initiate P-I/II Study of INO-4800 Against COVID-19 in South Korea

Jun 04, 2020 | Clinical Trial

23. Roche’s Elecsys IL-6 Test Receives the US FDA’s EUA to Identify Patients at High Risk of Severe Inflammatory Response with COVID-19

Jun 04, 2020 | Diagnostic

22. Novavax Awarded Department of Defense Contract for COVID-19 Vaccine

Jun 04, 2020 | Collaboration

21. Vapotherm to Expand Production Capacity in Advance of Potential Increase in Demand for High-Flow Nasal Cannula Systems for Treating COVID-19 Respiratory Distress

Jun 04, 2020 | Pharma

20. MyBio to launch Covid-19 antibody test in partnership with MöLab

Jun 04, 2020 | Diagnostic

19. Roche’s COVID-19 Ab Test Receives FDA’s EUA and is Available in Markets Accepting the CE Mark

Jun 04, 2020 | Diagnostic

18.  Novavax Collaborates with AGC Biologics to Manufacture Matrix-M Adjuvant for Novel COVID-19 Vaccine

Jun 03, 2020 | Collaboration

17.  Institutional Review Board (IRB) Review of Individual Patient Expanded Access Requests for Investigational Drugs and Biological Products During the COVID-19 Public Health Emergency Guidance for IRBs and Clinical Investigators

Jun 02, 2020 | Regulatory

16. Cellenkos Reports FDA Clearance to Initiate P-I Study of CK0802 for Treatment of COVID-19 Associated Acute Respiratory Distress Syndrome

Jun 02, 2020 | Regulatory

15. AgeX Therapeutics and ImStem Biotechnology Sign Non-Binding Letter of Intent Regarding Investigational MSC Candidate IMS001 for COVID-19 and Other Causes of ARDS

Jun 02, 2020 | Clinical Trial

14. Trevena Collaborates with Imperial College London to Evaluate TRV027 in COVID-19 Patients

Jun 02, 2020 | Clinical Trial

13. Lonza Sets New Goal to Make Moderna Covid-19 Vaccine Ingredients

Jun 02, 2020 | Clinical Trial

12.   UK’s Recovery Covid-19 Therapy Study Expected in Early July

Jun 02, 2020 | Clinical Trial

11. Gilead’s Remedesivir Receives EUA to Treat Patients with COVID-19

Jun 02, 2020 | Regulatory

10.  Agenus Receives IND Approval for iNKT Cells to Treat COVID-19 Patients

Jun 02, 2020 | Clinical Trial

9.  Bergenbio Dosed First Covid-19 Patient with Bemcentinib in Accord Trial

Jun 02, 2020 | Clinical Trial

7. Eight US Manufacturers Selected to Make NASA COVID-19 Ventilator

Jun 01, 2020 | Diagnostic

6. Genekam Develops Plasma Therapy Accelerator for COVID-19 Patients

Jun 01, 2020 | Diagnostic

5. Siemens Healthineers Receives FDA’s EUA for its SARS-CoV-2 Total Antibody Test that Delivers Superior Clinical Performance

Jun 01, 2020 | Diagnostic

4. Sema4 to Deliver High Capacity COVID-19 Testing in Partnership with the State of Connecticut

Jun 01, 2020 | Diagnostic

3. Eli Lilly Initiates the World’s First Clinical Study to Evaluate the Potential of COVID-19 Antibody Treatment in Humans

Jun 01, 2020 | Clinical Trial

2. Abiomed Receives EUA For Impella RP As Therapy For COVID-19 Patients with Right Heart Failure

Jun 01, 2020 | Regulatory

1. Gilead’s Remdesivir Shows Benefit in Patients with Moderate Covid-19

Jun 01, 2020 | Clinical Trial

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