Pfizer Reports Results of Clostridioides Difficile Vaccine in P-III (CLOVER) Trial for the Prevention of C. Difficile Infection
- The P-III (CLOVER) trial evaluates C. difficile vaccine vs PBO in 17500 adults aged ≥50yrs. with CDI with a high risk of CDI in a proximal time frame to receive the primary vaccine series
- The trial did not meet its pre-specified 1EPs of prevention of primary CDI & 2EPs include a favorable benefit in reducing CDI severity, vaccine efficacy (100%), median CDI duration (1 vs 4days) & mean duration (3 vs 16days), 75% & 80% reduction in disease episode, was well tolerated with a favorable safety profile
- Additionally, vaccine efficacy in 1EPs (28.6% & 31%), following 2nd & 3rd dose. For all CDI cases @14 days post dose 3, vaccine efficacy (49%/ 47%/ 31%) @~12/24mos. & at final analysis
Ref: Pfizer | Image: Pfizer
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