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Celltrion Reports Results of Herzuma (biosimilar, rastuzumab) + Gedatolisib in P-II Study for the Treatment of Metastatic Breast Cancer

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Celltrion Reports Results of Herzuma (biosimilar, rastuzumab) + Gedatolisib in P-II Study for the Treatment of Metastatic Breast Cancer

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  • The P-II study evaluates Herzuma (a trastuzumab biosimilar) + gedatolisib in patients with HER2–positive mBC with a PIK3CA aberration whose cancers had progressed after multiple lines of therapy
  • The results showed a 58.8% ORR with manageable toxicity, DCR was 82.4%, m-PFS was 5.9mos. Additionally, 3 patients had progressive disease, 4 with SD, and 10 showed PR. The results were presented at SABCS 2021
  • Trastuzumab is a mAb that targets HER2 & binds to the HER2/neu receptor and reduces HER2 expression along with the growth of blood vessels to support tumor growth while Gedatolisib targets the mTOR/PIK3 signaling pathway

Ref: Center for Biosimilars | Image: Celltrion 

Click here to­ read the full press release 

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