• Older patients (= 2 years and < 5 years) achieved a mean increase of 5.9 points from baseline in HFMSE scores, nearly double the clinically meaningful threshold (at a mean duration of follow-up time of 9.3 months)
• Untreated SMA Type 2 patients historically experience declining HFMSE scores over time, will never walk without support and often need a wheelchair.[1] More than 30% of patients with SMA Type 2 will die by age 25[2]

Basel, October 5, 2019?? AveXis, a Novartis company, today announced new interim data from the Phase 1/2 STRONG study for intrathecal (IT) administration of AVXS-101, demonstrating older patients (= 2 years and < 5 years) with spinal muscular atrophy (SMA) Type 2 achieved a mean increase of 5.9 points from baseline in HFMSE scores, nearly double the clinically meaningful threshold, at a mean duration of follow-up time of 9.3 months. This is up from a mean increase of 4.2 points from baseline in HFMSE scores presented in May 2019 at the American Academy of Neurology Annual Meeting. Half of the older patients with SMA Type 2 experienced a clinically meaningful response in motor function gains starting at one month post-treatment, defined as a = 3-point increase from baseline in HFMSE scores. HFMSE is a well-recognized functional scale used clinically and in clinical trials to measure physical abilities and motor function in non-ambulatory and ambulatory individuals with SMA Type 2 and 3.[6]?These data were presented at the 24^th?World Muscle Society (WMS) annual congress. ?Given the natural history of this devastating and rare genetic disease, many children will never stand or walk independently without therapeutic intervention. Today?s results ? although early ? are extremely encouraging for families who hope to see their children with SMA Type 2 experience meaningful improvement in motor function and important milestones, like standing and walking, following a one-time intrathecal administration of AVXS-101,? said Douglas M. Sproule, MD, vice president, SMA Therapeutic Head, AveXis. ?These data presented at the congress, along with long-term follow-up data from the STR1VE and SPR1NT studies, support a continually advancing body of evidence on the clinical impact gene therapy treatment may have for those fighting this devastating and rare genetic disease, regardless of type or severity.? Phase 1/2 STRONG Data?as of?May 31, 2019 STRONG is an ongoing, open-label, dose-comparison, multi-center trial designed to evaluate the efficacy, safety and tolerability of one-time IT administration of AVXS-101 in patients with SMA Type 2 who have three copies of the?SMN2?gene, and who are able to sit but cannot stand or walk at the time of study entry. Patients were divided into two groups based on age at time of treatment: patients who are =6 months but < 2 years and patients who are = 2 years but < 5 years. As of the data cut-off, 31 patients are enrolled and have been treated with one of three doses: Dose A (6.0 x 10[1][3] vg), Dose B (1.2 x 10[1][4] vg) and Dose C (2.4 x 10[1][4] vg). Data from Dose C were not presented at WMS. Three of 36 (8.3%) of patients screened were excluded due to elevated titers of anti-AAV9 antibodies. In patients = 6 months to < 2 years old:

• The primary efficacy endpoint is the ability to stand without support for = 3 seconds
• The secondary efficacy endpoint is the ability to walk independently for = 5 steps, according to the Bayley-III Gross Motor Milestone Scale
• Since treatment, 18 motor milestones were achieved among the 16 patients who received Dose A or Dose B, including two patients who gained the ability to stand independently, one of whom went on to walk alone

In patients = 2 years to < 5 years old:

• The primary efficacy endpoint is change in HFMSE score from baseline
• The secondary efficacy endpoint is the ability to walk independently for = 5 steps according to the Bayley-III Gross Motor Milestone Scale
• Patients showed a clinically meaningful improvement in motor function, having a mean 5.9-point increase from baseline in HFMSE scores at their most recent visit, at a mean duration of follow-up time of 9.3 months
  • In a responder analysis, half of patients (6/12) had a = 3-point increase, which was observed starting at one month post-treatment
• Since treatment, four motor milestones have been achieved among 12 patients in the Dose B group, including one patient who gained the ability to walk with assistance

All patients in STRONG study experienced at least one treatment emergent adverse event (TEAE) and 13 patients (43%) were reported to have a TEAE considered by the investigator to be related to treatment. Serious TEAEs were reported in 13% (n=4) of patients. A total of seven serious TEAEs were reported in four patients (n=1 each): influenza, pneumonia, respiratory syncytial virus infection, elevated ALT, elevated AST, blood alkaline phosphatase increased, and respiratory failure. Elevated ALT and AST (in one patient) were considered probably related to treatment. None of the serious TEAEs resulted in discontinuation from the study and no deaths were reported. About AVXS-101 Intrathecal Administration Investigational IT administration of AVXS-101 is currently being evaluated in patients with SMA Type 2 in a Phase 1/2 clinical trial. About?Spinal Muscular Atrophy (SMA) SMA is a severe neuromuscular disease characterized by the loss of motor neurons leading to progressive muscle weakness and paralysis. SMA is caused by a genetic defect in the?SMN1?gene that codes SMN, a protein necessary for survival of motor neurons.[3],[4] The incidence of SMA is approximately 1 in 10,000 live births and it is the leading genetic cause of infant mortality.[1],[4] The most severe form of SMA is Type 1, a lethal genetic disorder characterized by rapid motor neuron loss and associated muscle deterioration, resulting in mortality or the need for permanent ventilation support by 24 months of age for more than 90% of patients if left untreated.[5] Patients with SMA Type 2 typically have 3-4 copies of SMN2, will never walk without support and often need a wheelchair.1 More than 30% of patients with SMA Type 2 will die by age 25.[2] Disclaimer This media update contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be identified by words such as ?potential,? ?can,? ?will,? ?plan,? ?expect,? ?anticipate,? ?look forward,? ?believe,? ?committed,? ?investigational,? ?pipeline,? ?launch,? or similar terms, or by express or implied discussions regarding potential marketing approvals, new indications or labeling for the investigational or approved products described in this media update, or regarding potential future revenues from such products. You should not place undue reliance on these statements. Such forward-looking statements are based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that the investigational or approved products described in this media update will be submitted or approved for sale or for any additional indications or labeling in any market, or at any particular time. Nor can there be any guarantee that such products will be commercially successful in the future. In particular, our expectations regarding such products could be affected by, among other things, the uncertainties inherent in research and development, including clinical trial results and additional analysis of existing clinical data; regulatory actions or delays or government regulation generally; global trends toward health care cost containment, including government, payor and general public pricing and reimbursement pressures and requirements for increased pricing transparency; our ability to obtain or maintain proprietary intellectual property protection; the particular prescribing preferences of physicians and patients; general political and economic conditions; safety, quality or manufacturing issues; potential or actual data security and data privacy breaches, or disruptions of our information technology systems, and other risks and factors referred to in Novartis AG?s current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this media update as of this date and does not undertake any obligation to update any forward-looking statements contained in this media update as a result of new information, future events or otherwise. About AveXis AveXis, a Novartis company, is the world?s leading gene therapy company, redefining the possibilities for patients and families affected by life-threatening genetic diseases through our innovative gene therapy platform. Founded in 2013 and headquartered in Bannockburn, IL, the goal of AveXis? cutting-edge science is to address the underlying, genetic root cause of diseases. AveXis pioneered foundational research, establishing AAV9 as an ideal vector for gene transfer in diseases affecting the central nervous system, laying the groundwork to build a best-in-class, transformational gene therapy pipeline. AveXis received its first U.S. Food and Drug Administration approval in May 2019 for the treatment of spinal muscular atrophy (SMA). AveXis is also developing therapies for other genetic diseases, including Rett syndrome and a genetic form of amyotrophic lateral sclerosis (ALS) SOD1. For additional information, please visit?www.avexis.com. About Novartis Novartis is reimagining medicine to improve and extend people?s lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the world?s top companies investing in research and development. Novartis products reach more than 750 million people globally and we are finding innovative ways to expand access to our latest treatments. About 108,000 people of more than 140 nationalities work at Novartis around the world. Find out more at?www.novartis.com. Novartis is on Twitter. Sign up to follow @Novartis at?http://twitter.com/novartis?or?follow @NovartisNews for the latest News & Media Updates at?https://twitter.com/novartisnews. For Novartis multimedia content, please visit?www.novartis.com/news/media-library. For questions about the site or required registration, please contact?media.relations@novartis.com.

# # #

References

???????[1]?? Farrar MA, et al.?Ann Neurol.?2017;81(3):355-368. [2]?? Darras BT, Finkel RS Spinal Muscular Atrophy. Chapter 25 - Natural History of Spinal Muscular Atrophy. October 2017. [3]?? Anderton RS and Mastaglia FL.?Expert Rev Neurother. 2015;15(8):895-908. [4]?? National Organization for Rare Disorders (NORD). Spinal Muscular Atrophy.?http://rarediseases.org/rarediseases/spinal-muscular-atrophy/. Accessed?October 9, 2018. [5]?? Finkel RS, et al.?Neurology. 2014;83(9):810-7. [6]?? National Center for Biotechnology Information. Revised Hammersmith Scale for spinal muscular atrophy: A SMA specific clinical outcome assessment tool.?https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319655/. Accessed October 2, 2019. Novartis Media Relations E-mail:?media.relations@novartis.com

Eric Althoff Novartis External Communications +1 646 438 4335 (mobile) eric.althoff@novartis.com

Farah Bulsara Speer VP, Corporate Communications, AveXis +1 312 543 2881 (mobile) fSpeer259@avexis.com

Antonio Ligi Novartis Global External Communications +41 61 324 1374 (direct) antonio.ligi@novartis.com Novartis Investor Relations Central investor relations line: +41 61 324 7944 E-mail:?investor.relations@novartis.com