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Japan's AnGes aims to release coronavirus vaccine by end of year

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Japan's AnGes aims to release coronavirus vaccine by end of year

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Japan's AnGes aims to release coronavirus vaccine by end of year

TOKYO -- Japanese biotech venture?AnGes?is set to begin?a clinical trial of a?coronavirus vaccine in July, Nikkei learned Monday, raising?hopes?that the medication could secure?government approval by the end of the year. The clinical trial was originally slated to start in September, but the Ibaraki, Osaka Prefecture-based company has been able to bring forward the schedule, following?discussions with regulators and hospitals, thanks?to promising?results from animal tests, company officials said.
Unlike standard vaccines, which use live or inactivated pathogens to generate an immune response, DNA vaccines use a genetic sequence that causes cells within the body to produce an antigen for the virus -- the substance that the immune system learns to recognize. This lets drugmakers skip the time-consuming step of cultivating the virus in eggs or animals, slashing the time needed for production to six months from a year or more. DNA vaccines are?already?under development in other countries. Inovio Pharmaceuticals of the U.S., for instance, has been undertaking?a clinical trial. The results of?animal tests on the AnGes vaccine?showed an increase in antigens in?animals injected with the vaccine. Results for a?small-scale clinical trial, to be conducted at Osaka University and Osaka City University, are expected to come?as early as September and?will be followed by a larger-scale trial. If the effectiveness?is proven through these trials, the vaccine will be on course to?receive approval by the end of the year. The race for a coronavirus cure?is accelerating in many countries, including the U.S. and China. At least 10 candidates?are already?in clinical trials. The?U.S. aims to secure enough doses?for its?entire population and is?assisting?companies such as?Johnson & Johnson and Moderna in their efforts to launch mass production. AnGes, an Osaka University-affiliated biotechnology company, is planning to work with?Takara Bio?to produce 200,000 doses a year.  

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